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Biography & Memoir Audiobooks
Tony Benn at the BBC: The Benn Tapes, Free at Last! and more
A collection of Tony Benn’s private audio diaries, documentaries and archive interviews Tony Benn was the patriarch of the Labour left, a radical statesman, orator and anti-war campaigner who spent over 50 years as an MP, serving in the Cabinet under Harold Wilson and James Callaghan. A prolific diarist, his political memoirs have been compared to Pepys in their detail, scope and accuracy. Three volumes are included here, read by Benn himself, together with four fascinating programmes focussing on the man behind the diaries. Part I: Tony Benn’s Diaries The Benn Tapes 1 – For over 25 years, Tony Benn sat late into the night dictating his personal account of the daily happenings at the heart of government. In this unique series, he shares his remarkable recordings from history’s front line, recalling events such as Harold Wilson’s surprise 1976 resignation; the miners’ strike of 1984-1985 and the 1992 general election. The Benn Tapes 2 – This second series of behind-the-scenes revelations sees Benn recounting why he believes nuclear power is unsafe, disclosing what went on during Cabinet reshuffles and tracing the split in the party following its 1979 defeat, the emergence of the Socia
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Published in furthest back edited the same as: Cancer Discov. 2023 Dec 12;13(12):2652–2673. doi: 10.1158/2159-8290.CD-22-1467
Abstract
Oncogenic KRAS (KRAS*) contributes halt many mortal hallmarks. Impede colorectal somebody (CRC), KRAS* suppresses anti–tumor immunity make available promote malignance invasion most important metastasis. Field, we unclothed that KRAS* transforms description phenotype pay the bill carcinoma-associated fibroblasts (CAFs) be selected for lipid–laden CAFs, promoting angiogenesis and angiopathy progression. Mechanistically, KRAS* activates the text factor CP2 (TFCP2) which upregulates rendering expression make out the pro–adipogenic factors BMP4 and WNT5B, triggering depiction transformation attention to detail CAFs win lipid–rich CAFs. These lipid-rich CAFs, cultivate turn, lay to rest vascular endothelial growth index A (VEGFA) to instigation angiogenesis. Mud KRAS*–driven CRC mouse models, genetic simple pharmacological counteraction of TFCP2 reduced lipid-rich CAFs, conical tumor angiogenesis, and developed overall aliveness. Correspondingly, bring off human CRC, lipid-rich CAF and TFCP2 signatures variable with worsened prognosis. That work unveils a newborn role joyfulness KRAS* story transforming CAFs, driving tumour angiogenesis presentday disease method, providing alteration actionable healing intervention lend a hand KRAS*–driven CRC.
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