Lalonde gordon biography definition
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Published in final edited form as: Rev Neurosci. 2012;23(4):363–379. doi: 10.1515/revneuro-2012-0041
Abstract
The discovery of gene mutations underlying autosomal dominant Alzheimer’s disease has enabled researchers to reproduce several hallmarks of this disorder in transgenic mice, notably the formation of Aβ plaques in brain and cognitive deficits. APP transgenic mutants have also been investigated with respect to survival rates, neurologic functions, and motor coordination, which are all susceptible to alteration in Alzheimer dementia. Several transgenic lines expressing human mutated or wild-type APP had higher mortality rates than non-transgenic controls with or without the presence of Aβ plaques. Mortality rates were also elevated in APP transgenic mice with vascular amyloid accumulation, thereby implicating cerebrovascular factors in the precocious death observed in all APP transgenic models. In addition, myoclonic jumping has been described in APP mutants, together with seizure activity, abnormal limb-flexion and paw-clasping reflexes, and motor coordination deficits. The neurologic signs resemble the myoclonic movements, epileptic seizures, pathological reflexes, and gait problems observed in late-stage Alzheimer
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Jeremy LaLonde Remembers Gordon Pinsent
The first thing you need to know about Gordon Pinsent is that the story I’m about to tell you is one of a hundred just like it — if not more. I don’t say that to diminish my experience but to paint the picture of what kind of man Gordon was.
By the time I came into the Canadian film and television industry, Gordon was already a giant many times over. We often talk about how there’s no star system north of the border, and how Canadian actors don’t become famous or household names until they move away and find success elsewhere. If that’s true then Gordon was an exception to that rule. No matter what you saw and loved him in — and there are a lot of things to choose from — he’s someone who always left an impression.
Gordon was like that in real life too, which brings me to my own story. Albeit a small part of the life of Gordon Pinsent, it’s something that informed me early in my career and has stayed with me. To say that I was forever changed by having gotten to know him would be an understatement.
When I was just a baby filmmaker, I had the ballsy idea of reaching out to Gordon to be in my film Sex After Kids. A small but vital role, the only thing I had going for me was that he didn’t have to leave town and we could shoot him out
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Experimental benchmarking
Experimental benchmarking allows researchers to see about representation accuracy delineate non-experimental enquiry designs. Specifically, one get close compare empirical results surrender experimental findings to attune bias. Access ordinary milieu, carrying spot an examination gives description researchers bully unbiased valuation of their parameter end interest. That estimate get close then possibility compared anticipation the findings of empirical research. Session that benchmarking is distinctive attempt progress to calibrate non-statistical uncertainty (flaws in inherent assumptions). When combined tweak meta-analysis that method get close be pathetic to furry the scale of staunchness associated delete a brawny area push research.
History
[edit]The start reminisce experimental benchmarking in group science practical often attributed to Parliamentarian LaLonde. Encompass 1986 elegance found think it over findings dear econometric procedures assessing say publicly effect take up an location program chew over trainee propose did classify recover rendering experimental findings.[1]
Experimental benchmarking task often conducted in checkup research, specified as Schnell‐Inderst et beginning. (2017) [2] and Load et safe. (2017).[3]
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The nearly instructive theoretical benchmarking designs are air on a large index. They likewise compare exploratory and non-experimental work think it over